Background & objective: Fine needle aspiration CYTOLOGY (FNAC) is an easy, rapid, and less hazardous tool to diagnose the intra-abdominal lesions with various imaging modalities adding to its sensitivity and accuracy. However, sometimes it does not yield adequate information for precise diagnosis and the risk of false-negative and indeterminate diagnosis is always present. Cellblock preparations may be particularly helpful in such problematic cases. The current study aimed atevaluating and comparing the cytological as well as histopathological features of different intra-abdominal mass lesions. Methods: Image-guided FNAC followed by cell block were performed on 167 patients from June 2012 to May 2013. Histologically correlated 111 cases were evaluated. Results of conventional smear, cell block, and combination of FNAC with cell block were compared with histopathological findings regarding diagnostic sensitivity, specificity, and accuracy of diagnosis. Results: Cell block was more specific to diagnose these lesions than FNAC (95. 49% versus 90. 09%). Combined application of cell block with FNAC was more specific (96. 39%) than cell block alone with 100% diagnostic accuracy. Conclusion: Application of a combination of cell block with FNAC was more useful to diagnose intra-abdominal mass lesions.